Drug interactions
Frovatriptan + Pefloxacin
Severity: Minor
Frovatriptan and Pefloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pefloxacin inhibits CYP1A2, a pathway involved in frovatriptan clearance, and may raise frovatriptan levels. This could increase triptan adverse effects such as dizziness, fatigue and chest symptoms.
What this interaction means in plain words
Frovatriptan and Pefloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
Why it happens
Pefloxacin inhibits CYP1A2, reducing frovatriptan metabolism.
What to do
No routine dose change is required; monitor for increased adverse effects and stay within the maximum daily frovatriptan dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Pefloxacin
- Pefloxacin + Tizanidine Contraindicated
- Clozapine + Pefloxacin Major
- Duloxetine + Pefloxacin Major
- Pefloxacin + Theophylline Major
- Asenapine + Pefloxacin Moderate
- Caffeine + Pefloxacin Moderate
Frequently asked questions
Can I take Frovatriptan with Pefloxacin?
MediHelp rates the interaction as minor. Frovatriptan and Pefloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pefloxacin inhibits CYP1A2, a pathway involved in frovatriptan clearance, and may raise frovatriptan levels. This could increase triptan adverse effects such as dizziness, fatigue and chest symptoms.
How serious is the interaction between Frovatriptan and Pefloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for increased adverse effects and stay within the maximum daily frovatriptan dose.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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