Drug interactions
Frovatriptan + Selegiline
Severity: Moderate
Frovatriptan and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a triptan with an MAO inhibitor carries a theoretical risk of serotonin syndrome. Frovatriptan is not mainly metabolized by MAO-A, so the interaction is less likely to be pharmacokinetic.
What this interaction means in plain words
Frovatriptan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Additive serotonergic activity.
What to do
Use the lowest effective doses and counsel on symptoms of serotonin toxicity. Avoid the pairing with nonselective or transdermal selegiline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Selegiline?
MediHelp rates the interaction as moderate. Frovatriptan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a triptan with an MAO inhibitor carries a theoretical risk of serotonin syndrome. Frovatriptan is not mainly metabolized by MAO-A, so the interaction is less likely to be pharmacokinetic.
How serious is the interaction between Frovatriptan and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on symptoms of serotonin toxicity. Avoid the pairing with nonselective or transdermal selegiline.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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