Drug interactions
Gabapentin + Lemborexant
Severity: Moderate
Gabapentin and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a sedative-hypnotic and gabapentin also causes drowsiness. Together they may increase next-day somnolence and psychomotor impairment.
What this interaction means in plain words
Gabapentin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective lemborexant dose and monitor for daytime sedation. Counsel patients about driving and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Lemborexant
Frequently asked questions
Can I take Gabapentin with Lemborexant?
MediHelp rates the interaction as moderate. Gabapentin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is a sedative-hypnotic and gabapentin also causes drowsiness. Together they may increase next-day somnolence and psychomotor impairment.
How serious is the interaction between Gabapentin and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and monitor for daytime sedation. Counsel patients about driving and hazardous activities.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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