Drug interactions
Gabapentin + Levetiracetam
Severity: Minor
Gabapentin and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can produce somnolence, dizziness and fatigue, so combined use may cause more sedation. No important pharmacokinetic interaction exists, and the combination is common in practice.
What this interaction means in plain words
Gabapentin and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Warn the patient about drowsiness and impaired driving, especially during titration. Adjust doses if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gabapentin
Other interactions of Levetiracetam
Frequently asked questions
Can I take Gabapentin with Levetiracetam?
MediHelp rates the interaction as minor. Gabapentin and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can produce somnolence, dizziness and fatigue, so combined use may cause more sedation. No important pharmacokinetic interaction exists, and the combination is common in practice.
How serious is the interaction between Gabapentin and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and impaired driving, especially during titration. Adjust doses if sedation is excessive.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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