Drug interactions
Gabapentin + Maprotiline
Severity: Moderate
Gabapentin and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and together they may increase CNS depression and impair psychomotor performance. Respiratory depression is a particular concern in elderly patients, those with lung disease, or those taking other sedatives or opioids.
What this interaction means in plain words
Gabapentin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Start gabapentin at a low dose and titrate slowly while monitoring sedation and respiratory status. Warn the patient about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Maprotiline?
MediHelp rates the interaction as moderate. Gabapentin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and together they may increase CNS depression and impair psychomotor performance. Respiratory depression is a particular concern in elderly patients, those with lung disease, or those taking other sedatives or opioids.
How serious is the interaction between Gabapentin and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start gabapentin at a low dose and titrate slowly while monitoring sedation and respiratory status. Warn the patient about driving and alcohol.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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