Drug interactions
Gabapentin + Methohexital
Severity: Moderate
Gabapentin and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anaesthetic that causes marked CNS and respiratory depression. Gabapentin adds sedative effects and may deepen sedation or prolong recovery.
What this interaction means in plain words
Gabapentin and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Titrate methohexital carefully and monitor airway, oxygenation and level of consciousness, using continuous monitoring during procedures. Allow for a slower recovery in patients taking gabapentin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Methohexital
Frequently asked questions
Can I take Gabapentin with Methohexital?
MediHelp rates the interaction as moderate. Gabapentin and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anaesthetic that causes marked CNS and respiratory depression. Gabapentin adds sedative effects and may deepen sedation or prolong recovery.
How serious is the interaction between Gabapentin and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and monitor airway, oxygenation and level of consciousness, using continuous monitoring during procedures. Allow for a slower recovery in patients taking gabapentin.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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