Drug interactions
Gabapentin + Milnacipran
Severity: Moderate
Gabapentin and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin can cause sedation, dizziness and, with other CNS-active drugs, respiratory depression. Adding milnacipran may add to dizziness and somnolence, although serious respiratory effects are uncommon.
What this interaction means in plain words
Gabapentin and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Milnacipran belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Titrate slowly and monitor for sedation, dizziness and falls. Use extra care in elderly patients, those with respiratory disease or renal impairment, and adjust gabapentin for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Milnacipran?
MediHelp rates the interaction as moderate. Gabapentin and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin can cause sedation, dizziness and, with other CNS-active drugs, respiratory depression. Adding milnacipran may add to dizziness and somnolence, although serious respiratory effects are uncommon.
How serious is the interaction between Gabapentin and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate slowly and monitor for sedation, dizziness and falls. Use extra care in elderly patients, those with respiratory disease or renal impairment, and adjust gabapentin for renal function.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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