Drug interactions
Gabapentin + Sertraline
Severity: Minor
Gabapentin and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin causes sedation and dizziness, which may be additive with the CNS effects of sertraline. Serious respiratory depression is mainly a concern if opioids or other depressants are also taken.
What this interaction means in plain words
Gabapentin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS effects; no important pharmacokinetic interaction.
What to do
Titrate gabapentin gradually and counsel about drowsiness and impaired driving. Monitor for sedation, especially in older or frail patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Sertraline?
MediHelp rates the interaction as minor. Gabapentin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gabapentin causes sedation and dizziness, which may be additive with the CNS effects of sertraline. Serious respiratory depression is mainly a concern if opioids or other depressants are also taken.
How serious is the interaction between Gabapentin and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate gabapentin gradually and counsel about drowsiness and impaired driving. Monitor for sedation, especially in older or frail patients.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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