Drug interactions
Gabapentin + Tranylcypromine
Severity: Moderate
Gabapentin and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin causes sedation and, rarely, respiratory depression, and MAO inhibitors can add to CNS depression. Together they may increase drowsiness, dizziness and impaired psychomotor function, especially in older or medically fragile patients.
What this interaction means in plain words
Gabapentin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Start gabapentin at a low dose and titrate slowly, monitoring for excessive sedation, dizziness and respiratory depression. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Tranylcypromine?
MediHelp rates the interaction as moderate. Gabapentin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin causes sedation and, rarely, respiratory depression, and MAO inhibitors can add to CNS depression. Together they may increase drowsiness, dizziness and impaired psychomotor function, especially in older or medically fragile patients.
How serious is the interaction between Gabapentin and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start gabapentin at a low dose and titrate slowly, monitoring for excessive sedation, dizziness and respiratory depression. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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