Drug interactions
Gabapentin enacarbil + Remifentanil
Severity: Major
Gabapentin enacarbil and Remifentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentinoids combined with opioids raise the risk of sedation and respiratory depression, which can be fatal. The risk is greatest in older patients, those with lung disease, and at higher doses.
What this interaction means in plain words
Gabapentin enacarbil and Remifentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gabapentin enacarbil belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from gabapentinoid and opioid effects.
What to do
Use the lowest effective doses and monitor respiratory rate and sedation closely. Consider dose reduction of either drug in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Remifentanil?
MediHelp rates the interaction as major. Gabapentin enacarbil and Remifentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentinoids combined with opioids raise the risk of sedation and respiratory depression, which can be fatal. The risk is greatest in older patients, those with lung disease, and at higher doses.
How serious is the interaction between Gabapentin enacarbil and Remifentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor respiratory rate and sedation closely. Consider dose reduction of either drug in high-risk patients.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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