Drug interactions
Gabapentin enacarbil + Venlafaxine
Severity: Moderate
Gabapentin enacarbil and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil, a gabapentinoid prodrug, causes sedation and dizziness and can contribute to respiratory depression with other CNS-active drugs. Venlafaxine may cause somnolence or dizziness in some patients, so effects may add together.
What this interaction means in plain words
Gabapentin enacarbil and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective dose of gabapentin enacarbil and monitor for sedation, dizziness and impaired psychomotor function. Counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Venlafaxine?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil, a gabapentinoid prodrug, causes sedation and dizziness and can contribute to respiratory depression with other CNS-active drugs. Venlafaxine may cause somnolence or dizziness in some patients, so effects may add together.
How serious is the interaction between Gabapentin enacarbil and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of gabapentin enacarbil and monitor for sedation, dizziness and impaired psychomotor function. Counsel patients about driving.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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