Drug interactions
Gabapentin enacarbil + Zolpidem
Severity: Moderate
Gabapentin enacarbil and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and together they can cause excessive sedation, dizziness and respiratory depression. Risk is higher in older adults and in those with respiratory disease or renal impairment.
What this interaction means in plain words
Gabapentin enacarbil and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A modulation and gabapentinoid α2δ calcium channel binding.
What to do
Start at the lowest doses, and monitor for sedation, confusion and respiratory depression. Reduce the doses if drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Zolpidem?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, and together they can cause excessive sedation, dizziness and respiratory depression. Risk is higher in older adults and in those with respiratory disease or renal impairment.
How serious is the interaction between Gabapentin enacarbil and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at the lowest doses, and monitor for sedation, confusion and respiratory depression. Reduce the doses if drowsiness occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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