Drug interactions
Galantamine + Nilotinib
Severity: Moderate
Galantamine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and CYP2D6, which may raise galantamine levels. Both drugs can affect cardiac conduction (nilotinib prolongs QT, galantamine can cause bradycardia), so the combination warrants more attention than the pharmacokinetic effect alone.
What this interaction means in plain words
Galantamine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and CYP2D6 by nilotinib reduces galantamine metabolism, with additive cardiac conduction effects.
What to do
Obtain a baseline ECG and monitor heart rate and electrolytes during combined use. Reduce the galantamine dose if bradycardia or cholinergic effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Galantamine with Nilotinib?
MediHelp rates the interaction as moderate. Galantamine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and CYP2D6, which may raise galantamine levels. Both drugs can affect cardiac conduction (nilotinib prolongs QT, galantamine can cause bradycardia), so the combination warrants more attention than the pharmacokinetic effect alone.
How serious is the interaction between Galantamine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and electrolytes during combined use. Reduce the galantamine dose if bradycardia or cholinergic effects appear.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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