Drug interactions
Galantamine + Oxybutynin
Severity: Moderate
Galantamine and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Galantamine enhances cholinergic transmission while oxybutynin blocks it, so they oppose each other. This can reduce the cognitive benefit of galantamine and lessen the efficacy of oxybutynin.
What this interaction means in plain words
Galantamine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Avoid oxybutynin in dementia patients treated with galantamine where possible and consider an alternative such as mirabegron. If continued, monitor cognition and urinary symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Oxybutynin?
MediHelp rates the interaction as moderate. Galantamine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Galantamine enhances cholinergic transmission while oxybutynin blocks it, so they oppose each other. This can reduce the cognitive benefit of galantamine and lessen the efficacy of oxybutynin.
How serious is the interaction between Galantamine and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oxybutynin in dementia patients treated with galantamine where possible and consider an alternative such as mirabegron. If continued, monitor cognition and urinary symptoms.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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