Drug interactions
Galantamine + Tolterodine
Severity: Moderate
Galantamine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Galantamine enhances cholinergic transmission while tolterodine blocks muscarinic receptors, so the two drugs oppose each other. Tolterodine may reduce the cognitive benefit of galantamine and worsen confusion in dementia, while bladder symptoms may persist.
What this interaction means in plain words
Galantamine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Avoid the combination where possible and consider whether urinary symptoms are caused by the cholinesterase inhibitor. If an antimuscarinic is required, monitor cognition and function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Galantamine and Tolterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolterodine
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Tolterodine?
MediHelp rates the interaction as moderate. Galantamine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Galantamine enhances cholinergic transmission while tolterodine blocks muscarinic receptors, so the two drugs oppose each other. Tolterodine may reduce the cognitive benefit of galantamine and worsen confusion in dementia, while bladder symptoms may persist.
How serious is the interaction between Galantamine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider whether urinary symptoms are caused by the cholinesterase inhibitor. If an antimuscarinic is required, monitor cognition and function.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
