Drug interactions
Ganaxolone + Imipramine
Severity: Moderate
Ganaxolone and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid with sedative effects. Combined with imipramine it may produce additive somnolence and impaired alertness.
What this interaction means in plain words
Ganaxolone and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A modulation and tricyclic sedative effects.
What to do
Monitor for excessive sedation and reduce doses if needed. Counsel patients on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Imipramine?
MediHelp rates the interaction as moderate. Ganaxolone and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid with sedative effects. Combined with imipramine it may produce additive somnolence and impaired alertness.
How serious is the interaction between Ganaxolone and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce doses if needed. Counsel patients on driving and operating machinery.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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