Drug interactions
Ganaxolone + Methadone
Severity: Moderate
Ganaxolone and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system. Taken together they can increase drowsiness, impair psychomotor function and add to the risk of respiratory depression.
What this interaction means in plain words
Ganaxolone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression through opioid receptor agonism and GABA-A positive allosteric modulation.
What to do
Start ganaxolone at the standard dose and monitor for excessive sedation and slowed breathing. Advise patients to avoid driving and alcohol, and reduce the dose of either drug if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Methadone?
MediHelp rates the interaction as moderate. Ganaxolone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system. Taken together they can increase drowsiness, impair psychomotor function and add to the risk of respiratory depression.
How serious is the interaction between Ganaxolone and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start ganaxolone at the standard dose and monitor for excessive sedation and slowed breathing. Advise patients to avoid driving and alcohol, and reduce the dose of either drug if oversedation occurs.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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