Drug interactions
Ganaxolone + Morphine
Severity: Moderate
Ganaxolone and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid with sedative effects, and with morphine it may cause additive somnolence and respiratory depression. Concomitant CNS depressants are cautioned against in its labeling.
What this interaction means in plain words
Ganaxolone and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression through positive GABA-A modulation and opioid receptor agonism.
What to do
Monitor sedation and respiratory status, and reduce the dose of either drug if excessive somnolence occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Morphine?
MediHelp rates the interaction as moderate. Ganaxolone and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid with sedative effects, and with morphine it may cause additive somnolence and respiratory depression. Concomitant CNS depressants are cautioned against in its labeling.
How serious is the interaction between Ganaxolone and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and reduce the dose of either drug if excessive somnolence occurs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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