Drug interactions
Ganaxolone + Phenelzine
Severity: Moderate
Ganaxolone and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone causes somnolence and sedation, which may be additive with CNS depressant effects of an MAO inhibitor. This can impair alertness and coordination.
What this interaction means in plain words
Ganaxolone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and MAO inhibitor effects.
What to do
Monitor for excessive sedation and reduce the ganaxolone dose if needed. Advise caution with driving and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Phenelzine?
MediHelp rates the interaction as moderate. Ganaxolone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone causes somnolence and sedation, which may be additive with CNS depressant effects of an MAO inhibitor. This can impair alertness and coordination.
How serious is the interaction between Ganaxolone and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the ganaxolone dose if needed. Advise caution with driving and other CNS depressants.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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