Drug interactions
Ganaxolone + Promethazine
Severity: Moderate
Ganaxolone and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone commonly causes somnolence and sedation, and promethazine adds further sedating effects. The combination may result in excessive drowsiness and impaired alertness.
What this interaction means in plain words
Ganaxolone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive CNS depression through GABA-A positive modulation by ganaxolone and H1 antagonism by promethazine.
What to do
Monitor for excessive sedation and consider lowering the dose of one agent if drowsiness is troublesome; warn against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Promethazine?
MediHelp rates the interaction as moderate. Ganaxolone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone commonly causes somnolence and sedation, and promethazine adds further sedating effects. The combination may result in excessive drowsiness and impaired alertness.
How serious is the interaction between Ganaxolone and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider lowering the dose of one agent if drowsiness is troublesome; warn against driving.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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