Drug interactions
Ganciclovir + Indomethacin
Severity: Minor
Ganciclovir and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cleared by the kidney, and NSAIDs may reduce renal function or compete for tubular secretion, potentially raising ganciclovir exposure. Seizures have been reported with imipenem and ganciclovir, and ganciclovir toxicity such as myelosuppression may be increased if clearance falls.
What this interaction means in plain words
Ganciclovir and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganciclovir belongs to Anti Virals; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible competition for renal tubular secretion plus NSAID-related reduction in renal perfusion.
What to do
Monitor renal function and blood counts, and adjust ganciclovir dose to creatinine clearance if kidney function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Indomethacin?
MediHelp rates the interaction as minor. Ganciclovir and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are cleared by the kidney, and NSAIDs may reduce renal function or compete for tubular secretion, potentially raising ganciclovir exposure. Seizures have been reported with imipenem and ganciclovir, and ganciclovir toxicity such as myelosuppression may be increased if clearance falls.
How serious is the interaction between Ganciclovir and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and adjust ganciclovir dose to creatinine clearance if kidney function declines.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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