Drug interactions
Ganciclovir + Mesalamine
Severity: Minor
Ganciclovir and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cleared in part by renal tubular secretion, so mesalamine could theoretically reduce ganciclovir elimination. Mesalamine's systemic exposure is low and the clinical effect is expected to be small, but ganciclovir toxicity (myelosuppression, nephrotoxicity) is dose-related.
What this interaction means in plain words
Ganciclovir and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganciclovir belongs to Anti Virals; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Theoretical competition for renal tubular secretion between the salicylate metabolite and ganciclovir.
What to do
No routine change is needed; monitor blood counts and renal function as usual during ganciclovir therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Mesalamine?
MediHelp rates the interaction as minor. Ganciclovir and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are cleared in part by renal tubular secretion, so mesalamine could theoretically reduce ganciclovir elimination. Mesalamine's systemic exposure is low and the clinical effect is expected to be small, but ganciclovir toxicity (myelosuppression, nephrotoxicity) is dose-related.
How serious is the interaction between Ganciclovir and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood counts and renal function as usual during ganciclovir therapy.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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