Drug interactions
Ganciclovir + Probenecid
Severity: Moderate
Ganciclovir and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal clearance of ganciclovir, raising its exposure. Higher ganciclovir levels increase the risk of hematologic and other dose-related toxicity.
What this interaction means in plain words
Ganciclovir and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganciclovir belongs to Anti Virals; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits active renal tubular secretion of ganciclovir.
What to do
Monitor complete blood counts and renal function closely. Reduce the ganciclovir dose if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Probenecid?
MediHelp rates the interaction as moderate. Ganciclovir and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal clearance of ganciclovir, raising its exposure. Higher ganciclovir levels increase the risk of hematologic and other dose-related toxicity.
How serious is the interaction between Ganciclovir and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function closely. Reduce the ganciclovir dose if cytopenias develop.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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