Drug interactions
Ganciclovir + Tolfenamic acid
Severity: Minor
Ganciclovir and Tolfenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid is an NSAID that may compete with ganciclovir for renal tubular secretion and can reduce renal function. This might slightly increase ganciclovir exposure, although the effect is unlikely to be significant in most patients.
What this interaction means in plain words
Ganciclovir and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganciclovir belongs to Anti Virals; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Possible competition for anionic tubular secretion and NSAID effects on renal perfusion.
What to do
Monitor renal function and blood counts, and adjust ganciclovir dose according to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ganciclovir
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Ganciclovir with Tolfenamic acid?
MediHelp rates the interaction as minor. Ganciclovir and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolfenamic acid is an NSAID that may compete with ganciclovir for renal tubular secretion and can reduce renal function. This might slightly increase ganciclovir exposure, although the effect is unlikely to be significant in most patients.
How serious is the interaction between Ganciclovir and Tolfenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and adjust ganciclovir dose according to creatinine clearance.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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