Drug interactions
Ganciclovir + Trilaciclib
Severity: Moderate
Ganciclovir and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which take part in the renal secretion of drugs such as ganciclovir. This may raise ganciclovir exposure and the risk of its hematologic and renal toxicity.
What this interaction means in plain words
Ganciclovir and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganciclovir belongs to Anti Virals; Trilaciclib belongs to Oncology.
Why it happens
Inhibition of renal tubular secretion transporters (OCT2/MATE1/MATE2-K) may reduce ganciclovir clearance.
What to do
Monitor blood counts and renal function when the combination is used, and consider reducing the ganciclovir dose if toxicity appears. Avoid it if a suitable alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ganciclovir
Other interactions of Trilaciclib
Frequently asked questions
Can I take Ganciclovir with Trilaciclib?
MediHelp rates the interaction as moderate. Ganciclovir and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE2-K, which take part in the renal secretion of drugs such as ganciclovir. This may raise ganciclovir exposure and the risk of its hematologic and renal toxicity.
How serious is the interaction between Ganciclovir and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function when the combination is used, and consider reducing the ganciclovir dose if toxicity appears. Avoid it if a suitable alternative exists.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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