Drug interactions
Ganciclovir + Voclosporin
Severity: Moderate
Ganciclovir and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration and cause nephrotoxicity. Ganciclovir is renally eliminated, so reduced kidney function can raise its exposure and increase myelosuppression. Ganciclovir may also add to renal stress.
What this interaction means in plain words
Ganciclovir and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganciclovir belongs to Anti Virals; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity; voclosporin-induced reduction in renal function can reduce ganciclovir clearance.
What to do
Monitor serum creatinine, eGFR and blood counts regularly. Adjust ganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ganciclovir
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ganciclovir with Voclosporin?
MediHelp rates the interaction as moderate. Ganciclovir and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration and cause nephrotoxicity. Ganciclovir is renally eliminated, so reduced kidney function can raise its exposure and increase myelosuppression. Ganciclovir may also add to renal stress.
How serious is the interaction between Ganciclovir and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, eGFR and blood counts regularly. Adjust ganciclovir dose to creatinine clearance.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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