Drug interactions
Garlic + Tenecteplase
Severity: Moderate
Garlic and Tenecteplase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic supplements have antiplatelet activity and may add to the bleeding risk of tenecteplase. The evidence is mostly theoretical, but thrombolytic therapy carries a high intrinsic bleeding risk.
What this interaction means in plain words
Garlic and Tenecteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Garlic belongs to Gastrointestinal Tract; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive effects on hemostasis: garlic inhibits platelet aggregation while tenecteplase causes fibrinolysis.
What to do
Review supplement use before thrombolysis and advise discontinuing garlic supplements when possible. Monitor for bleeding after tenecteplase administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Garlic with Tenecteplase?
MediHelp rates the interaction as moderate. Garlic and Tenecteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Garlic supplements have antiplatelet activity and may add to the bleeding risk of tenecteplase. The evidence is mostly theoretical, but thrombolytic therapy carries a high intrinsic bleeding risk.
How serious is the interaction between Garlic and Tenecteplase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review supplement use before thrombolysis and advise discontinuing garlic supplements when possible. Monitor for bleeding after tenecteplase administration.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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