Drug interactions
Gemtuzumab + Levofloxacin
Severity: Moderate
Gemtuzumab and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT interval prolongation. Gemtuzumab ozogamicin labeling advises caution with QT-prolonging drugs, so concurrent levofloxacin may raise the risk of torsades de pointes, particularly in patients with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Gemtuzumab and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and serum potassium and magnesium before and during treatment, and correct abnormalities. Choose a non-QT-prolonging antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Gemtuzumab with Levofloxacin?
MediHelp rates the interaction as moderate. Gemtuzumab and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT interval prolongation. Gemtuzumab ozogamicin labeling advises caution with QT-prolonging drugs, so concurrent levofloxacin may raise the risk of torsades de pointes, particularly in patients with electrolyte disturbances or cardiac disease.
How serious is the interaction between Gemtuzumab and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and serum potassium and magnesium before and during treatment, and correct abnormalities. Choose a non-QT-prolonging antibiotic when feasible.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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