Drug interactions
Gemtuzumab + Propafenone
Severity: Moderate
Gemtuzumab and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin carries a QT prolongation warning, and propafenone also prolongs QT and slows conduction. Combined use may increase the risk of ventricular arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Gemtuzumab and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Check ECG and electrolytes before treatment, and monitor QTc during therapy. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Propafenone?
MediHelp rates the interaction as moderate. Gemtuzumab and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin carries a QT prolongation warning, and propafenone also prolongs QT and slows conduction. Combined use may increase the risk of ventricular arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Gemtuzumab and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before treatment, and monitor QTc during therapy. Correct potassium and magnesium abnormalities.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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