Drug interactions
Gemtuzumab + Quinidine
Severity: Moderate
Gemtuzumab and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, and gemtuzumab labeling advises ECG and electrolyte monitoring when given with QT-prolonging drugs. Combining them increases the risk of torsades de pointes, particularly with electrolyte disturbances.
What this interaction means in plain words
Gemtuzumab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and electrolytes before and during treatment, and correct potassium and magnesium. Consider an alternative to quinidine if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Quinidine?
MediHelp rates the interaction as moderate. Gemtuzumab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are associated with QT prolongation, and gemtuzumab labeling advises ECG and electrolyte monitoring when given with QT-prolonging drugs. Combining them increases the risk of torsades de pointes, particularly with electrolyte disturbances.
How serious is the interaction between Gemtuzumab and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes before and during treatment, and correct potassium and magnesium. Consider an alternative to quinidine if QTc becomes prolonged.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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