Drug interactions
Ginkgo biloba + Sulindac
Severity: Moderate
Ginkgo biloba and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo may inhibit platelet-activating factor and has been linked to case reports of bleeding. Combined with sulindac, which impairs platelet function and can injure the gastric mucosa, bleeding risk may rise.
What this interaction means in plain words
Ginkgo biloba and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects through platelet-activating factor antagonism and cyclooxygenase inhibition.
What to do
Advise avoiding ginkgo with sulindac where possible. If both are used, monitor for bleeding and stop ginkgo before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Ginkgo biloba with Sulindac?
MediHelp rates the interaction as moderate. Ginkgo biloba and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo may inhibit platelet-activating factor and has been linked to case reports of bleeding. Combined with sulindac, which impairs platelet function and can injure the gastric mucosa, bleeding risk may rise.
How serious is the interaction between Ginkgo biloba and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding ginkgo with sulindac where possible. If both are used, monitor for bleeding and stop ginkgo before surgery.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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