Drug interactions
Ginseng + Glyburide
Severity: Moderate
Ginseng and Glyburide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
American ginseng can lower blood glucose and may increase the risk of hypoglycemia with sulfonylureas such as glyburide.
What this interaction means in plain words
Ginseng and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ginseng belongs to Gastrointestinal Tract; Glyburide belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effect.
What to do
Monitor blood glucose when ginseng is started or stopped and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ginseng
- Acemetacin + Ginseng Moderate
- Alteplase + Ginseng Moderate
- Argatroban + Ginseng Moderate
- Aspirin / citric acid / sodium bicarbonate + Ginseng Moderate
- Aspirin rectal + Ginseng Moderate
- Aspirin + Ginseng Moderate
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Ginseng with Glyburide?
MediHelp rates the interaction as moderate. Ginseng and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. American ginseng can lower blood glucose and may increase the risk of hypoglycemia with sulfonylureas such as glyburide.
How serious is the interaction between Ginseng and Glyburide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ginseng is started or stopped and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Ginseng?
MediHelp also lists interactions of Ginseng with, for example, Acemetacin, Alteplase, Argatroban. The full list is on the Ginseng page.
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