Drug interactions
Ginseng + Sulindac
Severity: Moderate
Ginseng and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginseng may have antiplatelet activity, and sulindac inhibits platelet function and can injure the gastric mucosa. Combined use may increase bleeding risk, though clinical evidence is limited.
What this interaction means in plain words
Ginseng and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ginseng belongs to Gastrointestinal Tract; Sulindac belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects, with NSAID-related gastrointestinal mucosal injury.
What to do
Advise patients to report black stools, unusual bruising or bleeding. Use the lowest effective sulindac dose and stop ginseng if bleeding signs occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ginseng
- Acemetacin + Ginseng Moderate
- Alteplase + Ginseng Moderate
- Argatroban + Ginseng Moderate
- Aspirin / citric acid / sodium bicarbonate + Ginseng Moderate
- Aspirin rectal + Ginseng Moderate
- Aspirin + Ginseng Moderate
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Ginseng with Sulindac?
MediHelp rates the interaction as moderate. Ginseng and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginseng may have antiplatelet activity, and sulindac inhibits platelet function and can injure the gastric mucosa. Combined use may increase bleeding risk, though clinical evidence is limited.
How serious is the interaction between Ginseng and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report black stools, unusual bruising or bleeding. Use the lowest effective sulindac dose and stop ginseng if bleeding signs occur.
What other medicines interact with Ginseng?
MediHelp also lists interactions of Ginseng with, for example, Acemetacin, Alteplase, Argatroban. The full list is on the Ginseng page.
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