Drug interactions
Givinostat + Glipizide-metformin
Severity: Minor
Givinostat and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat may inhibit renal cation transporters involved in metformin elimination, which could modestly raise metformin exposure. The clinical significance is uncertain, but higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Givinostat and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible inhibition of renal organic cation transport reduces metformin clearance.
What to do
Monitor renal function and metformin tolerability, and consider dose reduction if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Glipizide-metformin?
MediHelp rates the interaction as minor. Givinostat and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat may inhibit renal cation transporters involved in metformin elimination, which could modestly raise metformin exposure. The clinical significance is uncertain, but higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Givinostat and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and metformin tolerability, and consider dose reduction if adverse effects develop.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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