Drug interactions
Givinostat + Glyburide-metformin
Severity: Minor
Givinostat and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat may weakly inhibit renal transporters involved in metformin elimination, which could slightly raise metformin levels. The effect is likely small, but is more relevant in patients with renal impairment.
What this interaction means in plain words
Givinostat and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible weak inhibition of renal organic cation transport reduces metformin clearance; the interaction is predicted from in vitro data.
What to do
Monitor renal function and metformin tolerability during co-administration. Reduce the metformin dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Givinostat and Glyburide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Glyburide-metformin?
MediHelp rates the interaction as minor. Givinostat and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat may weakly inhibit renal transporters involved in metformin elimination, which could slightly raise metformin levels. The effect is likely small, but is more relevant in patients with renal impairment.
How serious is the interaction between Givinostat and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and metformin tolerability during co-administration. Reduce the metformin dose if adverse effects emerge.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
