Drug interactions
Givinostat + Isoflurane
Severity: Major
Givinostat and Isoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and isoflurane has additive potential. Together they may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Givinostat and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givinostat belongs to Miscellaneous; Isoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain an ECG before and during the perioperative period and correct electrolyte abnormalities. Seek cardiology or anesthesia input if the QTc exceeds 500 ms or rises substantially from baseline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoflurane
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Isoflurane?
MediHelp rates the interaction as major. Givinostat and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval, and isoflurane has additive potential. Together they may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Givinostat and Isoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before and during the perioperative period and correct electrolyte abnormalities. Seek cardiology or anesthesia input if the QTc exceeds 500 ms or rises substantially from baseline.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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