Drug interactions
Givinostat + Metformin-pioglitazone
Severity: Minor
Givinostat and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat weakly inhibits renal organic cation transporters and may modestly increase metformin exposure. The clinical effect is expected to be small, but higher metformin levels raise the risk of gastrointestinal effects and rarely lactic acidosis.
What this interaction means in plain words
Givinostat and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Weak inhibition of renal cation transporters reduces tubular secretion of metformin.
What to do
Monitor for metformin adverse effects and renal function; reduce the metformin dose if intolerance develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Givinostat and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat weakly inhibits renal organic cation transporters and may modestly increase metformin exposure. The clinical effect is expected to be small, but higher metformin levels raise the risk of gastrointestinal effects and rarely lactic acidosis.
How serious is the interaction between Givinostat and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin adverse effects and renal function; reduce the metformin dose if intolerance develops.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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