Drug interactions
Givinostat + Metformin-repaglinide
Severity: Minor
Givinostat and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak inhibitor of CYP3A4 and of renal transporters involved in metformin handling. Exposure to repaglinide and metformin may rise modestly. The effect is usually small, but increased hypoglycemia or metformin adverse effects are possible.
What this interaction means in plain words
Givinostat and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4 (reducing repaglinide metabolism) and of renal organic cation transport (reducing metformin clearance).
What to do
Monitor blood glucose when givinostat is started or stopped. Reduce the antidiabetic dose if hypoglycemia or metformin intolerance appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Metformin-repaglinide?
MediHelp rates the interaction as minor. Givinostat and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak inhibitor of CYP3A4 and of renal transporters involved in metformin handling. Exposure to repaglinide and metformin may rise modestly. The effect is usually small, but increased hypoglycemia or metformin adverse effects are possible.
How serious is the interaction between Givinostat and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when givinostat is started or stopped. Reduce the antidiabetic dose if hypoglycemia or metformin intolerance appears.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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