Drug interactions
Givinostat + Nortriptyline
Severity: Moderate
Givinostat and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QTc interval, and nortriptyline has a similar effect. Together they may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Givinostat and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG at baseline and during concomitant use, and correct electrolyte abnormalities. Withhold givinostat if the QTc exceeds 500 ms or rises more than 60 ms from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Nortriptyline?
MediHelp rates the interaction as moderate. Givinostat and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QTc interval, and nortriptyline has a similar effect. Together they may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Givinostat and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during concomitant use, and correct electrolyte abnormalities. Withhold givinostat if the QTc exceeds 500 ms or rises more than 60 ms from baseline.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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