Drug interactions
Givinostat + Paroxetine
Severity: Moderate
Givinostat and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QTc interval, and paroxetine has a small potential for QT effects. Combined use may increase the risk of QT-related arrhythmia, especially with other risk factors.
What this interaction means in plain words
Givinostat and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Paroxetine belongs to Central Nervous System.
Why it happens
Possible additive QTc prolongation.
What to do
Obtain an ECG at baseline and during concurrent use, and correct potassium and magnesium abnormalities. Withhold givinostat if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Paroxetine?
MediHelp rates the interaction as moderate. Givinostat and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QTc interval, and paroxetine has a small potential for QT effects. Combined use may increase the risk of QT-related arrhythmia, especially with other risk factors.
How serious is the interaction between Givinostat and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during concurrent use, and correct potassium and magnesium abnormalities. Withhold givinostat if the QTc becomes markedly prolonged.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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