Drug interactions
Givinostat + Siponimod
Severity: Moderate
Givinostat and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and siponimod affects heart rate and conduction. Together they may increase the risk of serious arrhythmias such as torsades de pointes.
What this interaction means in plain words
Givinostat and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Siponimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarisation and conduction (pharmacodynamic).
What to do
Check ECG at baseline and during therapy, and correct electrolyte disturbances. Withhold givinostat if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Siponimod?
MediHelp rates the interaction as moderate. Givinostat and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and siponimod affects heart rate and conduction. Together they may increase the risk of serious arrhythmias such as torsades de pointes.
How serious is the interaction between Givinostat and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and during therapy, and correct electrolyte disturbances. Withhold givinostat if QTc becomes markedly prolonged.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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