Drug interactions
Givinostat + Sorafenib
Severity: Major
Givinostat and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and sorafenib has a similar effect. Together they may increase the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Givinostat and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givinostat belongs to Miscellaneous; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG at initiation and during combined use, and correct electrolyte abnormalities. Withhold givinostat if the QTc exceeds 500 ms or rises more than 60 ms from baseline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sorafenib
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Sorafenib?
MediHelp rates the interaction as major. Givinostat and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval, and sorafenib has a similar effect. Together they may increase the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Givinostat and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at initiation and during combined use, and correct electrolyte abnormalities. Withhold givinostat if the QTc exceeds 500 ms or rises more than 60 ms from baseline.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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