Drug interactions
Glasdegib + Lofexidine
Severity: Major
Glasdegib and Lofexidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. Bradycardia from lofexidine further adds to the risk.
What this interaction means in plain words
Glasdegib and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glasdegib belongs to Oncology; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid where an alternative exists; if combined, monitor ECG and electrolytes (potassium, magnesium) at baseline and regularly. Hold or reduce a drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Lofexidine?
MediHelp rates the interaction as major. Glasdegib and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. Bradycardia from lofexidine further adds to the risk.
How serious is the interaction between Glasdegib and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where an alternative exists; if combined, monitor ECG and electrolytes (potassium, magnesium) at baseline and regularly. Hold or reduce a drug if QTc becomes markedly prolonged.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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