Drug interactions
Glasdegib + Methadone
Severity: Major
Glasdegib and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib and methadone each can prolong the QT interval, so combined use raises the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Glasdegib and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glasdegib belongs to Oncology; Methadone belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid if an alternative exists. If combined, monitor ECG and electrolytes more frequently and correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Methadone?
MediHelp rates the interaction as major. Glasdegib and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glasdegib and methadone each can prolong the QT interval, so combined use raises the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Glasdegib and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If combined, monitor ECG and electrolytes more frequently and correct potassium and magnesium abnormalities.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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