Drug interactions
Glasdegib + Nilotinib
Severity: Major
Glasdegib and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so using them together may produce additive effects. The risk of torsades de pointes and other serious arrhythmias is increased.
What this interaction means in plain words
Glasdegib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glasdegib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Choose alternatives if possible. If both are needed, monitor ECG and electrolytes regularly and correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Nilotinib?
MediHelp rates the interaction as major. Glasdegib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so using them together may produce additive effects. The risk of torsades de pointes and other serious arrhythmias is increased.
How serious is the interaction between Glasdegib and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose alternatives if possible. If both are needed, monitor ECG and electrolytes regularly and correct potassium and magnesium abnormalities.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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