Drug interactions
Glasdegib + Triptorelin
Severity: Moderate
Glasdegib and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and triptorelin may contribute through androgen deprivation. Concurrent use may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Glasdegib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically, and correct abnormalities. Interrupt or reduce glasdegib per labeling if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Triptorelin?
MediHelp rates the interaction as moderate. Glasdegib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and triptorelin may contribute through androgen deprivation. Concurrent use may increase the risk of ventricular arrhythmia.
How serious is the interaction between Glasdegib and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, and correct abnormalities. Interrupt or reduce glasdegib per labeling if QTc becomes markedly prolonged.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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