Drug interactions
Glecaprevir / pibrentasvir + Imatinib
Severity: Moderate
Glecaprevir / pibrentasvir and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, BCRP and OATP transporters and may increase imatinib exposure. Imatinib could also modestly raise glecaprevir levels via CYP3A4 inhibition. Clinical significance is likely modest but increased imatinib adverse effects are possible.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-gp/BCRP/OATP transport by glecaprevir/pibrentasvir increases imatinib exposure, and imatinib inhibits CYP3A4.
What to do
Monitor for imatinib adverse effects such as edema, cytopenias and liver enzyme elevation, and for hepatic tolerability during HCV therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Imatinib?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein, BCRP and OATP transporters and may increase imatinib exposure. Imatinib could also modestly raise glecaprevir levels via CYP3A4 inhibition. Clinical significance is likely modest but increased imatinib adverse effects are possible.
How serious is the interaction between Glecaprevir / pibrentasvir and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects such as edema, cytopenias and liver enzyme elevation, and for hepatic tolerability during HCV therapy.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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