Drug interactions
Glecaprevir / pibrentasvir + Lapatinib
Severity: Moderate
Glecaprevir / pibrentasvir and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp and BCRP, which may raise lapatinib absorption and exposure. Lapatinib, also an inhibitor of these transporters, may in turn raise glecaprevir/pibrentasvir levels.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual inhibition of P-glycoprotein and BCRP transport.
What to do
Monitor for lapatinib adverse effects such as diarrhea, hepatotoxicity and QT prolongation, and reduce the lapatinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Lapatinib?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-gp and BCRP, which may raise lapatinib absorption and exposure. Lapatinib, also an inhibitor of these transporters, may in turn raise glecaprevir/pibrentasvir levels.
How serious is the interaction between Glecaprevir / pibrentasvir and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib adverse effects such as diarrhea, hepatotoxicity and QT prolongation, and reduce the lapatinib dose if toxicity occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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