Drug interactions
Glecaprevir / pibrentasvir + Lidocaine-prilocaine
Severity: Minor
Glecaprevir / pibrentasvir and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could slightly raise lidocaine exposure. Since lidocaine is a minor P-gp substrate and topical absorption is limited, the clinical effect is expected to be negligible.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by glecaprevir/pibrentasvir may reduce lidocaine efflux.
What to do
No dose change is needed for standard topical use. Limit the treated area and duration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glecaprevir / pibrentasvir and Lidocaine-prilocaine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could slightly raise lidocaine exposure. Since lidocaine is a minor P-gp substrate and topical absorption is limited, the clinical effect is expected to be negligible.
How serious is the interaction between Glecaprevir / pibrentasvir and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed for standard topical use. Limit the treated area and duration.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
