Drug interactions
Glecaprevir / pibrentasvir + Mifepristone
Severity: Minor
Glecaprevir / pibrentasvir and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may inhibit CYP3A4 and transporters involved in glecaprevir and pibrentasvir disposition, possibly raising their exposure. The clinical effect is modest and the combination is usually tolerated.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mifepristone inhibition of CYP3A4 and possibly P-gp may modestly raise levels of these antivirals.
What to do
No routine dose change is needed. Monitor for gastrointestinal effects and liver tests.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Mifepristone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone may inhibit CYP3A4 and transporters involved in glecaprevir and pibrentasvir disposition, possibly raising their exposure. The clinical effect is modest and the combination is usually tolerated.
How serious is the interaction between Glecaprevir / pibrentasvir and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for gastrointestinal effects and liver tests.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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